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NAC may be supportive in APD by: Helping replenish glutathione, which plays a role in regulating immune responses Reducing oxidative stress that can worsen mast cell activation and inflammation Supporting overall inflammatory balance, particularly during hormonally driven immune flares Some research also suggests NAC may influence mast cell–mediated pathways indirectly [13] , which may be relevant in conditions where histamine release contributes to symptoms

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Renal conjugate C-S lyase mediated toxicity of halogenated alkenes in primary cultures of human and rat proximal tubular cells