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however, its selectivity toward GLS1 and failure to inhibit the compensatory effect of GLS2 require in-depth study 14

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Pathological conditions, such as high-dose salicylate administration, are known to increase NMDA receptor expression and function, leading to elevated calcium influx, mitochondrial dysfunction, ROS production, and excitotoxic neuronal injury, which are hallmarks of the tinnitus state (Song et al., 2021)