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Activation of α M β 2 by TLR2/TLR4 required Rac1-GTP loading, PI3K activity, and cytohesin-1 binding to the β 2 subunit (72).The role of cytohesin-1 is controversial, as the use of cytohesin-1 siRNAs and inhibitors results in an increase in the α M β 2 affinity conformation (73)
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By comparison, perispinal applications (such as facet joint or epidural injections) have received less research attention for discogenic pain, and existing evidence suggests intradiscal administration may more effectively address disc pathology itself [12]
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