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Standard cycle: 4–6 weeks Extended cycle with monitoring: up to 12 weeks for complex or chronic presentations Rest period between cycles: 4–8 weeks is typical Duration matters because tissue remodeling continues for weeks after a cycle ends
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Moreover, InrS is the only Ni/Co specific sensor crystallized to date and is thus far unique among CsoR-family members in that it has been shown to repress the expression of genes encoding Ni II efflux transporters, while promoting the expression of Ni II uptake genes
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