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37 Research has shown that depletion of GSH not only directly inhibits GPX4, but also indirectly activates the Fenton reaction, releasing Fe 2+ and promoting ROS generation, further exacerbating cell damage

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In fact, contamination from degrading/leaking erythrocytes can artificially increase GSH and GSSG levels in both plasma and serum, given that these cells contain approximately two orders of magnitude higher glutathione than the liquid portion of blood (Tomin et al., 2021)