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As demonstrated by Sugino et al., estrogen and progesterone withdrawal at the end of the secretory phase may upregulate ROS and downregulate SOD, with the former triggering a sequential cascade that starts by activating nuclear factor kappa-light chain enhancer of activated B cells (NF-κB) and cyclooxygenase-2 and ends with prostaglandin F 2α production, culminating in endometrial shedding [17]
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