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Additionally, p-values displayed above the 'All models' (green) plots indicate statistical significance between the top-performing dataset and the combined group (HCMI + CCLE), calculated via two-sided Mann-Whitney U-tests with BH correction (lung: p=3.0x10 −6

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Functional studies in receptor-deficient models further confirm that β3-adrenergic signaling is essential to its activity, positioning AOD 9604 as a tool for dissecting receptor-mediated lipid mobilization [1]