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Although numerous preclinical studies have demonstrated significant therapeutic potential of targeting ferroptosis pathways—such as using iron chelators, modulating GPX4 activity, or inhibiting lipid peroxidation—recent clinical trial results indicate that strategies aiming solely to reduce iron accumulation may have limited efficacy in clinical practice

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Author contributions Mahmoud Hussein Hadwan (Conceptualization [equal], Data curation [equal], Formal analysis [equal], Funding acquisition [equal], Investigation [equal], Methodology [equal], Project administration [equal], Resources [equal], Software [equal], Supervision [equal], Validation [equal], Visualization [equal], Writing—original draft [equal], and Writing—review & editing [equal]), Abbas Ali Mohammed (Data curation [equal], Investigation [equal], Methodology [equal], Software [equal], and Writing—review & editing [equal]), Saeed Najavand (Data curation [equal], Project administration [equal], Resources [equal], Software [equal], Supervision [equal], Investigation [equal], Methodology [equal], and Writing—review & editing [equal]), Roaa Altaee (Investigation [equal], Methodology [equal], Validation [equal], and Writing—review & editing [equal]), and Asad Hadwan (Data curation [equal], Formal analysis [equal], Investigation [equal], Methodology [equal], Validation [equal], and Writing—review & editing [equal]) Conflicts of interest None declared