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103,104,105,106 However, a variety of stimuli, including nutrient perturbation, genotoxic stress, infection, pollutants and xenobiotics, trigger ROS overproduction, resulting in excessive oxidant challenge (oxidative distress)

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This contrasted with the spared gross liver presentation, counteracted hepatomegaly and splenomegaly, reduced gross lesions in the stomach, duodenum and intestine, lower serum enzyme values, and no congestion of the central vein or branches of the terminal portal venules in BPC 157-treated rats