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Crossing these Jnk1 LoxP/LoxP / Jnk2 -/- mice with Alb-Cre mice produced Jnk Δhepa ( Jnk Δhepa mice developed higher liver injury than wild-type animals after APAP overdose, suggesting a beneficial role for combined Jnk1 and Jnk2 activation in hepatocytes during APAP-induced hepatotoxicity

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The clinical translation is still maturing