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Specifically, we removed the cPCs increased in the HCMI dataset, which were similarly enriched for immune-related gene signatures (Supplementary Fig
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B12 injections are most clearly indicated when: A person has confirmed B12 deficiency that requires rapid replacement There’s a known or likely absorption issue There’s a need for ongoing maintenance due to non-dietary causes (for example, autoimmune gastritis) Typical treatment schedules (UK guidance) Treatment schedules can vary depending on symptoms, severity, and cause