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Conversely, others using different animal models did not show beneficial effects on infarct size in non-preconditioned rats (Dai and Kloner, 2003) or in coronary artery occlusion/reperfusion rabbits (Hale and Kloner, 2004), however all suggest that acetaminophen is a safe drug in the postmyocardial infarction setting (Dai and Kloner, 2003