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Preclinical animal work A 2026 Frontiers in Endocrinology review of the growth hormone and IGF-1 axis across performance enhancing peptides, including where fragment molecules sit relative to secretagogues A 2004 Current Opinion in Investigational Drugs review of the Metabolic Pharmaceuticals clinical development programme for AOD9604 as an anti-obesity candidate A 2015 Drug Testing and Analysis paper on the in vitro metabolism and mass spectrometry detection of AOD9604 for anti-doping purposes, not a clinical study Predictors of Treatment Response to Tesamorelin, a Growth Hormone-Releasing Factor Analog, in HIV-Infected Patients with Excess Abdominal Fat
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During maturation, the NOTCH precursor undergoes a complex process of modifications and cleavages, like the S1 cleavage catalyzed by a furin-like protease before translocation of the mature protein to the cell membrane (Figure 6)