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Consistent with human observations, H2O2 also promoted FOXO4 nuclear translocation in TM3 cells, along with an increase in senescence markers p53, phospho-p53, and p21, while reducing testosterone synthesis-related enzymes like CYP11A1 and CYP17A1
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However, that study also employed a small dose of phosphatidic acid, another soy-based phospholipid.105 Saffron Saffron is a popular herb in central Asian cuisine, and its bioactive compounds — called safranals — have been implicated in various health benefits