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However, a recent study revealed that female patients with newly diagnosed Hashimoto’s thyroiditis had significantly reduced serum GSH concentrations than matched control subjects and concluded that decreased GSH levels were associated with immunological response (38)

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For SDS-PAGE and Western blotting studies, SEC-purified shelterin was diluted to 0.9 µM and incubated with increasing concentrations of compound 40 or 60 (negative control) in the same range as for the MP experiment (from 0 to 300 µM)