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Further, mice treated with SRT1720, a potent, selective synthetic activator of SIRT1, were resistant to diet-induced obesity and insulin resistance due to enhanced oxidative metabolism in skeletal muscle, liver, and brown adipose tissue (see Supplementary Information)

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Vomiting occurs less frequently than nausea but may affect fifteen to twenty percent of patients, particularly those who experience severe nausea or those who do not implement dietary modifications to manage gastrointestinal symptoms