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Local vs Systemic Influence BPC-157 is commonly discussed in relation to: Tendon and ligament support Tissue recovery Muscle recovery Gut support Circulatory support TB-500 is often viewed as even more systemic in nature and is frequently associated with: Mobility support Connective tissue recovery Recovery from widespread strain patterns Muscle support throughout the body Because of this, many practitioners focus less on chasing exact injection locations and more on maintaining consistent systemic support over time