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Freezing at minus 20 degrees Celsius reduces reaction rates substantially (Arrhenius kinetics: roughly a 2- to 3-fold rate reduction per 10 degrees Celsius drop)
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Athira's trials of the related MET modulator fosgonimeton did exclude anyone with a history of or newly diagnosed malignancy, though that exclusion appears in the ADDF summary alongside routine epilepsy and cardiac exclusions and should not be over-read as a MET-specific signal
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