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GSH inhibits PSC activation and proliferation induced by LOsG in vivo and in vitro PSC activation is a critical event in pancreatic fibrosis, and activated PSCs have characteristics such as high proliferation and increased ECM secretion
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89 Conventionally, GDH (coded by the GLUD gene) is the more predominant enzymes vital for the reactions needed to replenish the TCA cycle and yield NADPH than GOT2 and GPT2, which consists of ubiquitously expressed GDH1 and GDH2 mainly existing in neuronal and testicular tissue and having lower activity than GDH1
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