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The ischemia and reperfusion may occur in the cardiac surgeries, where the re-oxigenation can cause serious arrhythmias with extense lesions due to the oxygen paradoxal shock, which causes ATP depletion during the ischemia, forming hypoxanthine or xanthine, that work like a substrate to the xanthine oxidase enzyme (XO), precursor form the uric acid, that acts like na antioxidant in these cases
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