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In Experiment 2, to determine the effects of NAC on behavioral scores and CNS metabolites after acute withdrawal, all methadone-exposed pups received naloxone HCl (1 mg/kg, i.p.) and either NAC (50 mg/kg, n = 2, or 100 mg/kg, n = 7) or an equal volume of saline i.p
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Reversing this pathophysiology and providing supportive care is accomplished through intramuscular epinephrine (increases systemic vascular resistance and decreases bronchoconstriction), intravenous H1/H2 blockers (decreases vasodilation and third-spacing), nebulized beta-agonists (relieves bronchospasm), intravenous glucocorticoids (anti-inflammatory), and intravenous fluids (intravascular resuscitation, increases cardiac output)