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In the secondary analysis, EN-RAGE was nominally associated with recurrent stroke (HR: 1.21 [1.00-1.45], p = 0.045)

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The key differences that make this fragment scientifically interesting are: Absence of IGF-1 stimulation: Unlike full-length GH, this compound does not appear to stimulate hepatic IGF-1 production in laboratory models, an important distinction for researchers wishing to study metabolic GH-related pathways without the confounding variable of IGF-1 pathway activation