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One of the drugs that is effectively employed currently in cerebral stroke therapy is the Semax (Met-Glu-His-Phe-Pro-Gly-Pro), which is a synthetic peptide consisting of a fragment of ACTH(4–7) and the C-terminal tripeptide Pro-Gly-Pro (PGP)

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Research published in The AAPS Journal confirms subcutaneous injections bypass enzymatic degradation and first-pass metabolism, resulting in higher systemic exposure and tighter control over therapeutic concentrations