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Comparative analysis showed that D-CuP exhibited higher binding affinities than its monomeric counterpart M-CuP, with Vina scores of -5.7 kcal/mol for p53 and -6.4 kcal/mol for HDAC7, compared to -4.2 kcal/mol and -4.8 kcal/mol for M-CuP, respectively (Fig

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This is because berberine derivatives can cross the blood-brain barrier and target mitochondria in the meantime (Wang L