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Furthermore, M1 macrophages generate abundant ROS and secrete pro-inflammatory cytokines (e.g., TNF-α, IL-6), which propagate lipid peroxidation and impair antioxidant mechanisms in neighboring structural cells (127)
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Some practitioners in integrative or functional medicine clinics do direct patients to compounding pharmacies or research chemical suppliers, but this operates in a regulatory gray zone and the clinical liability falls entirely on the prescriber and patient
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